منابع مشابه
Endoneurial fibroblast-like cells.
Endoneurial fibroblast-like cells (EFLCs) have been described for more than 60 years, but the embryology, functions, and pathology of these cells are not well defined. Several hypotheses of their origin have been proposed. A previous study suggesting that they were of neural crest origin is supported by our data in humans. This lineage might account for EFLCs having multiple biologic functions ...
متن کاملCarcinoma-associated fibroblast-like differentiation of human mesenchymal stem cells.
Carcinoma-associated fibroblasts (CAF) have recently been implicated in important aspects of epithelial solid tumor biology, such as neoplastic progression, tumor growth, angiogenesis, and metastasis. However, neither the source of CAFs nor the differences between CAFs and fibroblasts from nonneoplastic tissue have been well defined. In this study, we show that human bone marrow-derived mesench...
متن کاملOsteoclast-independent bone resorption by fibroblast-like cells
To date, mesenchymal cells have only been associated with bone resorption indirectly, and it has been hypothesized that the degradation of bone is associated exclusively with specific functions of osteoclasts. Here we show, in aseptic prosthesis loosening, that aggressive fibroblasts at the bone surface actively contribute to bone resorption and that this is independent of osteoclasts. In two s...
متن کاملFibroblast-like cells on intraocular lens implants: phagocytosing erythrocytes.
An intraocular lens implant had to be removed 4 years after its implantation from the eye of a patient on warfarin (Coumadin) medication because of repeated intraocular haemorrhages. Implant cytology staining revealed a continuous membrane on the removed implant that contained relatively few large foreign body giant cells and great numbers of small fibroblast-like cells. An impressive clean-up ...
متن کاملGPR39 Is Coupled to TMEM16A in Intestinal Fibroblast-Like Cells
GPR39 is a GPCR implicated as a regulator of gastrointestinal motility, although the mechanism remains elusive. Here, we report that GPR39 is expressed by a specific cell population cultured from mouse small intestine muscle layers, which was subsequently identified as fibroblast-like cells (FLCs) that have recently been shown to modulate gut motility. Application of the GPR39 agonist, Zn(2+), ...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 2012
ISSN: 0022-3069,1554-6578
DOI: 10.1097/nen.0b013e318270a941